2x2 by Donald W. Miller, Jr., M.D. KEYWORDS: SENSITIVITY, SPECIFICITY, LIKELIHOOD RATIO, PREDICTIVE VALUE, TESTS, MEDICINE, NEWTON This is a simple, no frills application that will calculate predictive values and likelihood ratios from patient data, sensitivity and specificity of diagnostic tests. It is also helpful in demonstrating the interaction between prevalence and sensitivity, specificity. 2x2 works with Newton OS 1.x and 2.0. This application is freeware. However, 2x2 is copyrighted by Donald W. Miller, Jr. with all rights reserved. It may be copied freely, but if distributed for profit, written permission must be obtained from the author. For comments, questions, or accolades send email to: DrMiller@aol.com